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Junior Faculty Position - Biostatistics

Faculty/ Pharmacoepidemiology and Pharmacoeconomics, DOM  

GENERAL SUMMARY/ OVERVIEW STATEMENT:

The Division of Pharmacoepidemiology and Pharmacoeconomics of the Brigham and Women's Hospital seeks a junior faculty member in biostatistics to join our growing program.

We are a world-leading research division at Harvard Medical School that studies the use, effectiveness and safety of medical products in clinical practice. We have direct access to large amounts of up-to-date patient-level longitudinal data. Our biostatistics group collaborates closely with other biostatisticians, epidemiologists and physicians, both internally and at the nearby Harvard Medical School and T.H. Chan School of Public Health, to implement research studies. In addition to ongoing applied research activities, we have a portfolio of methods-focused projects funded by the FDA and NIH, many of which aim to improve estimation of causal treatment effects in non-randomized data.

An academic rank of Instructor or Assistant Professor at Harvard Medical School will be commensurate with experience, training and achievements. The successful candidate will collaborate and provide statistical guidance in ongoing research projects, build their own research program, and engage in teaching and mentoring students in the classroom and within the Division.

Further information about our research programs can be found on the Division website.

QUALIFICATIONS:

Applicants should have excellent graduate training in biostatistics or statistics and may have additional research experience.  

WORK ENVIRONMENT:

Hybrid with in-person and remote activities in compliance with the facility and MA government guidelines. While in office, professional office environment, business casual. Working with a tight-knit, helpful, dedicated group of friendly people including over 20 Harvard Medical School faculty and 40 support members, including 8+ experienced programmers.

Employment at a Partners HealthCare System (“Partners”) affiliate is contingent upon:
- United States Citizenship and Immigration Services rules concerning identity and right to work in the United States
- Multi-state criminal background checks
- Pre-employment health and drug screening and annual compliance with the Influenza Vaccination Policy        

TO APPLY:
Please address a c.v. and a cover letter describing your interest to Sebastian Schneeweiss, M.D., Sc.D., Chief of the Division of Pharmacoepidemiology and Pharmacoeconomics and Professor of Medicine at Harvard Medical School, and submit via e-mail to Lewis Seton.

EEO Statement: We are an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, pregnancy and pregnancy-related conditions or any other characteristic protected by law. Women and minority candidates are particularly encouraged to apply.

Primary Location: MA-Boston-BWH Boston Main Campus
Work Locations: BWH Boston Main Campus 75 Francis St  Boston 02115
Job: Junior Faculty
Organization: Brigham & Women's Hospital(BWH)
Schedule: Full-time
Standard Hours: 40
Shift: Day Job
Posted Shift Description: Day / 40 hrs
Employee Status: Regular
Recruiting Department: BWH Department Of Medicine / Pharmocoepidemiology

Research Fellow - Medical Informatics

Research Fellow Medical Informatics/Day/40 hours/ Pharmacoepidemiology and Pharmacoeconomics, DOM  
GENERAL SUMMARY/ OVERVIEW STATEMENT:

The Division of Pharmacoepidemiology and Pharmacoeconomics of the Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School is accepting applications for one postdoctoral fellow in medical informatics. The Division is a 100- member interdisciplinary research center that brings together the various specialties of medicine, epidemiology, informatics, biostatistics, health services research, and regulatory sciences to evaluate the safety and effectiveness of prescription drugs in clinical practice; to study how medications are prescribed and used; to develop methods to optimize prescription drug use; to understand how medicines are approved and regulated after their marketing. The Division houses the FDA Sentinel Innovation Center with a rapidly growing data asset that links electronic health records (EHR) + insurance claims data for multi-million patients.

We are seeking one self-motivated, diligent, and independent fellow to work with Division faculty in medical informatics. The overarching objective is to answer high-impact questions to inform clinical decision-making on the comparative effectiveness and safety of medications, by analyzing large scale EHR linked with insurance claims data using cutting-edge artificial intelligence and informatics techniques. The fellow will collaborate closely with Division faculty who are leaders in the field of medical informatics. A fellow working in this area will aim to improve estimation of causal treatment effects by making increasing use of unstructured and semi-structured data from EHR and insurance claims. The ideal candidate would be a team player and have a doctoral degree in natural language processing, feature engineering, artificial intelligence, or medical informatics.

The Research Fellow will have an appointment at Harvard Medical School, receive close mentorship from faculty members in the Division and on the Harvard Medical Campus, and engage in one or more projects intended to advance their careers in medical informatics or artificial intelligence in healthcare. He/she will be highly encouraged to publish the results of their research during the appointment period. This opportunity is suited to individuals who are both independently motivated and collaborative and who thrive in a vibrant research environment working as part of a large team of experienced faculty and staff. The Fellow must be comfortable giving and receiving feedback and integrating this feedback into their work. He/she must enjoy recognizing the ideas and contributions of their colleagues and be comfortable being transparent in their work and decision-making. Please see Division website for more information on faculty and research topics.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

The duties and responsibilities will vary depending on the specific topic area in which the fellow works, but will generally include:
1. Researching, developing, designing, executing, and interpreting medical informatics studies in the specific topic areas.
2. Collaborating with clinical colleagues on applied informatic techniques.
3. Investigating, creating, and applying new artificial intelligence or medical informatics algorithms for research advancement in the specified topic areas.
4. Developing automated informatics systems and pipelines for medical processes and visualizing analytic results.
5. Contributing to the scientific literature by way of reports, journal articles, and presentations.

QUALIFICATIONS:

Applications are invited from researchers with doctoral degrees (PhD/ScD/DrPH, MD, PharmD, or equivalent) and strong research and publication records in natural language processing, feature engineering, artificial intelligence, and medical informatics. Candidates are expected to have experience in developing artificial intelligence models with statistical machine learning and cutting-edge deep learning algorithms (e.g. Transformers, Large Language Models). Experience analyzing healthcare data (e.g., claims, EHR) or causal inference research is desirable, but not required.

SKILLS/ABILITIES/COMPETENCIES:
- Outstanding team player.
- Strong programming skills and experience of artificial intelligence model development.
- Strong research design and analytical skills.
- Meticulous in all aspects of their work.
- Excellent time management and organizational skills.
- Ability to thrive in a dynamic environment and to adapt to shifting priorities, demands, and timelines.
- Strong written and oral communication skills.
- A willingness to learn new methods and tools relevant to their research is a must.

WORK ENVIRONMENT:

Hybrid with in-person and remote activities in compliance with the facility and MA government guidelines.

TO APPLY:
If interested, please send your CV and cover letter to Lewis Seton.

EEO Statement: We are an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, pregnancy and pregnancy-related conditions or any other characteristic protected by law. Women and minority candidates are particularly encouraged to apply.

Primary Location: MA-Boston-BWH Boston Main Campus
Work Locations: BWH Boston Main Campus 75 Francis St  Boston 02115
Job: Research - Other
Organization: Brigham & Women's Hospital (BWH)
Schedule: Full-time
Standard Hours: 40
Shift: Day Job
Posted Shift Description: Day / 40 hrs
Employee Status: Regular
Recruiting Department: BWH Department Of Medicine / Pharmocoepidemiology


Employment at a Partners HealthCare System (“Partners”) affiliate is contingent upon:
- United States Citizenship and Immigration Services rules concerning identity and right to work in the United States
- Multi-state criminal background checks
- Pre-employment health and drug screening and annual compliance with the Influenza Vaccination Policy        

Post-Doctoral Fellowship in Pediatric Real-World Evidence Research

Post-Doctoral Fellowship in Pediatric Real-World Evidence Research at the Harvard-MIT Center for Regulatory Science 

GENERAL SUMMARY/ OVERVIEW STATEMENT:

The Harvard-MIT Center for Regulatory Science is a partnership between Harvard, MIT and the FDA, focused on building innovative approaches for the development and evaluation of medical products. Working across academia, industry, and government institutions, the Center promotes regulatory science through research and education programs, uniting stakeholders under a common mission: to promote optimal patient health outcomes through biomedical innovation and the availability of safe and effective treatments.

Regulatory science brings together a range of scientific disciplines to assess the quality, safety, and effectiveness of therapeutics, helping to inform regulatory decision-making over the lifecycle of drugs, devices, and vaccines. The Regulatory Science Fellowship Program draws individuals with diverse expertise who are passionate about developing and applying novel methods in therapeutic science and contributing to the multi-disciplinary community of the Center.

ABOUT THE POSITION:

The Harvard-MIT Center for Regulatory Science, in close collaboration with the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Boston Children’s Hospital, all at Harvard Medical School, is seeking a post-doctoral research fellow interested in the intersection of pediatric real-world evidence research with regulatory science. This includes pharmacoepidemiology research as it relates to the supplemental regulatory approval of medications for pediatric use. Up to 50% of medications in the outpatient setting and 80% in the inpatient setting are used off-label in pediatric patients. There is increasing interest in evaluating the suitability of real-world evidence studies to form the basis for supplemental regulatory approval of medications to be used in pediatric patients that were previously approved in adult patients. The fellow will conduct pediatric pharmacoepidemiology studies of medication safety and effectiveness using large claims and electronic health record data sources and study how that impacts the regulation of medications in children.  

The Division of Pharmacoepidemiology is an international leader in training and research on the safety and effectiveness of medications, applying advanced analytic methods to diverse large healthcare databases. It houses the FDA Sentinel Innovation Center and is working closely with FDA, EMA and NIH on a range of projects relevant to regulatory science. For this position, the fellow will work directly under the mentorship of Drs. Sebastian Schneeweiss and Tim Savage and with Dr. Florence Bourgeois, Co-Director of the Harvard-MIT Center for Regulatory Science. The fellow will be expected to participate in international conferences and publish conference and journal papers.

Unique aspects of this fellowship program include:
1. Access to FDA scientists and collaborations on FDA projects
2. Participation in an established multi-disciplinary community, enabling educational experiences and research activities outside of a single field of expertise
3. Access to clinicians and investigators at multiple large healthcare centers, providing opportunities for research projects with direct medical applications

BASIC QUALIFICATIONS:
Doctoral degrees (MD, PhD, PharmD, or equivalent) and training or experience in healthcare data science, clinical pediatrics, clinical pharmacology, pharmacoepidemiology, epidemiology, or health services research.

APPLICATION PROCEDURE AND REQUIREMENTS:
Please include the following in the initial application to be submitted to Lewis Seton:
1. Curriculum vitae
2. Cover letter
3. Research statement describing the applicant's research interests, including a description of the relevance to regulatory science in pediatric populations.
4. Writing sample or up to three relevant publications.

If selected to submit a full application, candidates will be interviewed and asked to provide:
1. Three letters of reference
2. Project description (3 pages maximum) that includes justification for the work, specific research objectives, proposed methods, and the project's broader relevance and implications for regulatory science. The project description may be developed jointly with the mentor following submission of the initial application.

EEO Statement:
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

Host Institution: Harvard Medical School
Appointing Department:
Harvard Program in Therapeutic Science
Location:
Boston, MA
Category:
Research Fellow
Other responsibilities:
no administrative or teaching obligations
Duration of Fellowship;
2 years

CONTACT:
Sebastian Schneeweiss, MD, ScD
Chief, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital
Professor of Medicine, Harvard Medical School
Sschneeweiss@bwh.harvard.edu  

Florence Bourgeois, MD, MPH
Co-Director, Harvard-MIT Center for Regulatory Science Computational Health Informatics Program and Division of Emergency Medicine, Boston Children’s Hospital
Associate Professor of Pediatrics, Harvard Medical School
Florence_Bourgeois@hms.harvard.edu

Research Fellow - Geriatric Pharmacoepidemiology

Research Fellow Geriatric Pharmacoepidemiology/ Day/ 40 Hrs Pharmacoepidemiology & Pharmacoeconomics, DOM 

GENERAL SUMMARY/ OVERVIEW STATEMENT:

The Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women’s Hospital Department of Medicine and Harvard Medical School (the Division) is accepting applications for several postdoctoral fellows in pharmacoepidemiology. The Division is a 100-member interdisciplinary research center that brings together the various specialties of medicine, epidemiology, biostatistics, health services research, legal, regulatory and the social sciences to evaluate the effectiveness of prescription drugs in relation to their risks and costs; to study how medications are prescribed and used; to develop methods to optimize prescription drug use; to understand how medicines are approved and regulated after their marketing.

We are seeking one or more self-motivated, diligent, and independent fellows to work with Division faculty in geriatric pharmacoepidemiology. The overarching objective is to answer high-impact questions to inform clinical decision-making on the comparative effectiveness and safety of medications in geriatric pharmacoepidemiology by applying and advancing cutting-edge methods. The fellows will collaborate closely with Division faculty who are leaders in the field of geriatric pharmacoepidemiology. A fellow working in this area will answer critical clinical questions on the prescribing and deprescribing of medications and their comparative effectiveness and safety in older adults leveraging real-world data, including administrative claims, electronic health records, Minimum Data Set (MDS), Outcomes, and Assessment Information Set (OASIS), Inpatient Rehabilitation Facility Patient Assessment Instrument (IRF-PAI), a variety of clinical assessment and survey files, with the opportunity to lead several important research studies each year. The ideal candidate would be a team player and have a doctoral degree in epidemiology, aging research, or clinical geriatrics.  Having a clinical background or a degree in medicine combined with epidemiology training is desirable.

Fellows will have an appointment at Harvard Medical School, receive close mentorship from faculty members in the Division, and engage in one or more projects intended to advance their careers in Geriatric pharmacoepidemiology or Causal inference method development research. Fellows will be highly encouraged to publish the results of their research during the appointment period. This opportunity is suited to individuals who are both independently motivated and collaborative and who thrive in a vibrant research environment working as part of a large team of experienced faculty and staff. Fellows must be comfortable giving and receiving feedback and integrating this feedback into their work. Fellows must enjoy recognizing the ideas and contributions of their colleagues and be comfortable being transparent in their work and decision-making. Please see Division website for more information on faculty and research topics.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

The duties and responsibilities will vary depending on the specific topic area in which the fellow works, but will generally include:
1. Researching, developing, designing, executing, and interpreting epidemiologic studies in the specific topic areas.
2. Collaborating with methodologic and clinical colleagues on applied and/or methodological studies.
3. Investigating, creating, and applying new methods and technologies for research advancement in the specified topic areas.
4. Contributing to the scientific literature by way of reports, journals articles, and presentations.

QUALIFICATIONS:

Applications are invited from researchers with doctoral degrees (PhD/ScD/DrPH, MD, PharmD, or equivalent) and strong research and publication records in epidemiology, statistics, bioinformatics, or clinical medicine. Candidates are expected to have experience analyzing healthcare data (e.g., claims, EHR). Strong programming skills are desirable, but not required.

SKILLS/ABILITIES/COMPETENCIES:

- Outstanding team player.
- Strong research design and analytical skills.
- Meticulous in all aspects of their work.
- Excellent time management and organizational skills.
- Ability to thrive in a dynamic environment and to adapt to shifting priorities, demands, and timelines.
- Strong written and oral communication skills.
- Strong programing skills are highly desirable and a willingness to learn new methods and tools relevant to their research is a must.

WORKING CONDITIONS:

Hybrid with in-person and remote activities in compliance with the facility and MA government guidelines

TO APPLY:

If interested, please send your CV and cover letter to Lewis Seton.  

EEO Statement:
BWH is an Affirmative Action Employer.   By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Primary Location: MA-Boston-BWH Boston Main Campus
Work Locations: BWH Boston Main Campus 75 Francis St  Boston 02115
Job: Research - Other
Organization: Brigham & Women's Hospital(BWH)
Schedule: Full-time
Standard Hours: 40
Shift: Day Job
Posted Shift Description: Day / 40 hrs
Employee Status: Regular
Recruiting Department: BWH Department Of Medicine / Pharmocoepidemiology

Employment at a Partners HealthCare System (“Partners”) affiliate is contingent upon:
- United States Citizenship and Immigration Services rules concerning identity and right to work in the United States
- Multi-state criminal background checks
- Pre-employment health and drug screening and annual compliance with the Influenza Vaccination Policy

Research Specialist - Pharmacoepidemiology & Pharmacoeconomics

Research Specialist - DOM Pharmacoepidemiology & Pharmacoeconomics (3224712)

GENERAL SUMMARY/ OVERVIEW STATEMENT:

Functioning under the direction of the principal investigators and other faculty members, the Research Specialist works independently to conduct high level, complex research study design and analysis in the areas of pharmacoepidemiology, epidemiology/biostatistics, and analytic methods. Contributes to scientific literature, reports, journals, manuscripts (including co-authorship as appropriate), presentations, and grant writing. Works in close-knit, internationally known research unit of 25+ Harvard faculty and 60+ support staff.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

Under the direction of principal investigators, assists in the designing, planning, and execution of analyses of therapeutic outcomes and adverse effects of drugs and other medical interventions, as well as simulation studies evaluating epidemiologic methods and validation studies in claims data, applying skills in biostatistics, epidemiologic methods, and health services research. Serves as an integral part of the research team, helps to analyze and interpret data findings, prepare summaries, reports and presentations based on analysis and results. Conducts systematic reviews and helps oversee large prospective quality improvement trials being conducted to improve long-term medication adherence and health outcomes. Contributes to the scientific literature through oral and poster presentations and published manuscripts. Assists with grant proposals and project management, as needed. The research specialist will be involved in projects related to the pharmacoepidemiology of metabolic diseases and perinatal pharmacoepidemiology, amongst others.

Specific duties include:
1. Research, develop, design and execute and interpret research data
2. Contribute to interpretation of research data and results
3. Contribute to scientific literature, journals, and oral presentations
4. Participate in study design and protocol development
5. Participate in Institutional Review Board (IRB) submission process for new research protocols
6. Take part in design and writing of grant proposals and grant material
7. Compose and present sections of research reports and manuscripts
8. Perform advanced data analysis, working closely with the Principal Investigator and other researchers
9. Perform other duties as assigned

QUALIFICATIONS:

- MS (or equivalent) or doctoral degree in Epidemiology, Biostatistics, or related field; emphasis on methods and or pharmaco-epidemiology preferred; healthcare-related doctoral degree a plus
- Ideally 2 years of relevant experience
- Excellent knowledge of epidemiologic methods; focus on pharmacoepidemiology desirable
- Experience in research using large claims databases desirable
- Experience in collaborative projects with clinical medicine is preferred
- Knowledge and skills in the critical appraisal of research evidence are highly desired
- Background in pharmaceuticals is advantageous

SKILLS/ABILITIES/COMPETENCIES:
The successful candidate will have very good methodologic and analytic skills in epidemiology to help implement these research projects, with knowledge of pharmacoepidemiology an added advantage. The candidate must have the abilities to design and analyze complex epidemiologic claims data analyses under the supervision of the principal investigators, to perform major database manipulation and statistical analyses using statistical packages, and to draft study reports for funding agencies. Strong time management/organizational skills as well as written and verbal presentation skills are necessary. An understanding of clinical medicine is an advantage but not required. Familiarity with pharmaceuticals is desirable.

WORKING CONDITIONS:

Professional office environment. Business casual. Some days remote.

SUPERVISORY RESPONSIBILITY: None.
FISCAL RESPONSIBILITY: None.

HOSPITAL WIDE RESPONSIBILITIES: Works within legal, regulatory, accreditation and ethical practice standards relevant to the position and as established by BWH/Partners; follows safe practices required for the position; complies with appropriate BWH and Partners policies and procedures; fulfills any training required by BWH and/or Partners, as appropriate; brings potential matters of non-compliance to the attention of the supervisor or other appropriate hospital staff.

EEO Statement:
Brigham and Women’s Hospital (BWH) complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, citizenship, alienage, religion, creed, sex, sexual orientation, gender identity, age, or disability. BWH does not exclude people or treat them differently because of race, color, national origin, citizenship, alienage, religion, creed, sex, sexual orientation, gender identity, age, or disability.

Primary Location: MA-Boston-BWH Boston Main Campus
Work Locations: BWH Boston Main Campus 75 Francis St, Boston, MA 02115
Job: Research - Other
Organization: Brigham & Women's Hospital (BWH)
Schedule: Full-time
Standard Hours: 40
Shift: Day Job
Posted Shift Description: Day / 40 hrs
Employee Status: Regular
Recruiting Department: BWH Department Of Medicine / Pharmocoepidemiology

Apply Here

Research Specialist Pharmacoepidemiology & Pharmacoeconomics

Research Specialist - DOM Pharmacoepidemiology & Pharmacoeconomics (3224713)

GENERAL SUMMARY/ OVERVIEW STATEMENT:

Functioning under the direction of the principal investigators and other faculty members, the Research Specialist works independently to conduct high level, complex research study design and analysis in the areas of pharmacoepidemiology, epidemiology/biostatistics, and analytic methods. Contributes to scientific literature, reports, journals, manuscripts (including co-authorship as appropriate), presentations, and grant writing. Works in close-knit, internationally known research unit of 25+ Harvard faculty and 60+ support staff.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

Under the direction of principal investigators, assists in the designing, planning, and execution of analyses of therapeutic outcomes and adverse effects of drugs and other medical interventions, as well as simulation studies evaluating epidemiologic methods and validation studies in claims data, applying skills in biostatistics, epidemiologic methods, and health services research. Serves as an integral part of the research team, helps to analyze and interpret data findings, prepare summaries, reports and presentations based on analysis and results. Conducts systematic reviews and helps oversee large prospective quality improvement trials being conducted to improve long-term medication adherence and health outcomes. Contributes to the scientific literature through oral and poster presentations and published manuscripts. Assists with grant proposals and project management, as needed. The research specialist will be involved in projects related to the pharmacoepidemiology of metabolic diseases and perinatal pharmacoepidemiology, amongst others.

Specific duties include:
1. Research, develop, design and execute and interpret research data
2. Contribute to interpretation of research data and results
3. Contribute to scientific literature, journals, and oral presentations
4. Participate in study design and protocol development
5. Participate in Institutional Review Board (IRB) submission process for new research protocols
6. Take part in design and writing of grant proposals and grant material
7. Compose and present sections of research reports and manuscripts
8. Perform advanced data analysis, working closely with the Principal Investigator and other researchers
9. Perform other duties as assigned

QUALIFICATIONS:

- MS (or equivalent) or doctoral degree in Epidemiology, Biostatistics, or related field; emphasis on methods and or pharmaco-epidemiology preferred; healthcare-related doctoral degree a plus
- Ideally 2 years of relevant experience
- Excellent knowledge of epidemiologic methods; focus on pharmacoepidemiology desirable
- Experience in research using large claims databases desirable
- Experience in collaborative projects with clinical medicine is preferred
- Knowledge and skills in the critical appraisal of research evidence are highly desired
- Background in pharmaceuticals is advantageous

SKILLS/ABILITIES/COMPETENCIES:
The successful candidate will have very good methodologic and analytic skills in epidemiology to help implement these research projects, with knowledge of pharmacoepidemiology an added advantage. The candidate must have the abilities to design and analyze complex epidemiologic claims data analyses under the supervision of the principal investigators, to perform major database manipulation and statistical analyses using statistical packages, and to draft study reports for funding agencies. Strong time management/organizational skills as well as written and verbal presentation skills are necessary. An understanding of clinical medicine is an advantage but not required. Familiarity with pharmaceuticals is desirable.

WORKING CONDITIONS:

Professional office environment. Business casual. Some days remote.

SUPERVISORY RESPONSIBILITY: None.
FISCAL RESPONSIBILITY: None.

HOSPITAL WIDE RESPONSIBILITIES: Works within legal, regulatory, accreditation and ethical practice standards relevant to the position and as established by BWH/Partners; follows safe practices required for the position; complies with appropriate BWH and Partners policies and procedures; fulfills any training required by BWH and/or Partners, as appropriate; brings potential matters of non-compliance to the attention of the supervisor or other appropriate hospital staff.

EEO Statement:
Brigham and Women’s Hospital (BWH) complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, citizenship, alienage, religion, creed, sex, sexual orientation, gender identity, age, or disability. BWH does not exclude people or treat them differently because of race, color, national origin, citizenship, alienage, religion, creed, sex, sexual orientation, gender identity, age, or disability.

Primary Location: MA-Boston-BWH Boston Main Campus
Work Locations: BWH Boston Main Campus 75 Francis St, Boston, MA 02115
Job: Research - Other
Organization: Brigham & Women's Hospital (BWH)
Schedule: Full-time
Standard Hours: 40
Shift: Day Job
Posted Shift Description: Day / 40 hrs
Employee Status: Regular
Recruiting Department: BWH Department Of Medicine / Pharmocoepidemiology

Apply Here

Project Coordinator Pharmacoepidemiology

Project Coordinator - DOM Pharmacoepidemiology & Pharmacoeconomics (3226914)

Drug Pricing Policy Program Coordinator - Program on Regulation, Therapeutics and Law (PORTAL)

GENERAL SUMMARY/ OVERVIEW STATEMENT:

We are seeking a program coordinator to join a collaborative, interdisciplinary health policy research group that focuses on prescription drug utilization and policy. The Program On Regulation, Therapeutics, And Law (PORTAL) includes faculty researchers, analysts, and trainees from the fields of medicine, law, epidemiology, and health policy. The members of PORTAL develop and publish evidence related to issues related to use, cost, and regulation of prescription drug and other medical products. This work, which is published in peer-reviewed medical and health policy journals, is leveraged to promote thoughtful policies that support evidence-based, equitable, and cost-effective patient care. Our work is funded by grants and contracts from government and non-profit organizations. PORTAL is a based within the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women's Hospital and Harvard Medical School.


PRINCIPAL DUTIES AND RESPONSIBILITIES:

The role of the project coordinator will be to support the research team members, coordinate projects, manage interactions with funders and policy makers, and manage program staff and trainees. The project coordinator will be expected to actively participate in multiple projects related to prescription drug cost, use, and regulation.  One example will be our work with the National State Academy of Health Policy (NASHP) to help advise and implement new state policies to improve prescription drug affordability.


Specific tasks will include:
- Coordinating communication between PORTAL and funders, policy makers, and collaborators, including scheduling and documenting meetings.
- Drafting and editing materials that summarize our work for relevant stakeholders, including presentation slides, memos, white papers, summaries for the lay press.
- Providing administrative support for projects, including management of institutional review board applications, grants, contracts, assessing deliverables, and preparing required reports for funders.
- Supporting PORTAL team members by ensuring that projects move efficiently toward completion and publication.
- Establishing connections to federal and state legislators and regulators to understand their current drug pricing policy priorities, develop ideas about impactful and responsive work PORTAL can undertake, and inform them about evidence that PORTAL has generated.
- Working with PORTAL team members to summarize and disseminate published studies to relevant policymakers and stakeholders at the federal and state level, including through meetings, presentations, memos, white papers, or Op-Eds.
- Providing oversight and management for PORTAL’s trainees, students, and research assistants.

REQUIRED QUALIFICATIONS:

1. Masters’ degree in a relevant field (e.g., MPH, MS, MPP) or at least 2 years of equivalent work experience.
2. Interest and experience with health policy, academic research, and writing.
3. Excellent organizational, problem-solving, and interpersonal skills.
4. Ability to effectively communicate both through writing and oral presentations.
5. Proficient in Microsoft Outlook, Word, Powerpoint, and Excel.
6. By Division policy, personal consulting relationships with pharmaceutical or medical device companies are prohibited while working at PORTAL or in the Division.

PREFERRED QUALIFICATIONS:

1. Experience analyzing and working with large data sets using statistical software (e.g. R, Stata, or SAS)
2. Experience working in a research environment and familiarity with manuscript publications and grants.
3. Management or leadership experience.

EEO Statement:
Brigham and Women’s Hospital (BWH) complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, citizenship, alienage, religion, creed, sex, sexual orientation, gender identity, age, or disability. BWH does not exclude people or treat them differently because of race, color, national origin, citizenship, alienage, religion, creed, sex, sexual orientation, gender identity, age, or disability.

Primary Location: MA-Boston-BWH Boston Main Campus
Work Locations: BWH Boston Main Campus 75 Francis St, Boston, MA 02115
Job: Professional/Managerial
Organization: Brigham & Women's Hospital (BWH)
Schedule: Full-time
Standard Hours: 40
Shift: Day Job
Posted Shift Description: Full time Day - Hybrid
Employee Status: Regular
Recruiting Department: BWH Department Of Medicine / Pharmocoepidemiology

Apply Here

IS 'R' Programmer Analyst Sr. Pharmacoepidemiology

IS 'R' Programmer Analyst Sr. - DOM Pharmacoepidemiology & Pharmacoeconomics (3226920)

GENERAL SUMMARY/ OVERVIEW STATEMENT:

The Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women's Hospital and Harvard Medical School was created to facilitate a wide range of activities related to the use and outcomes of medications. Its mission is to bring together the various specialties of medicine, epidemiology, biostatistics, health services research, and the social sciences to evaluate the effectiveness of existing and new prescription drugs in relation to their risks and costs; to study how medications are used by physicians and patients; and to develop methods to optimize prescription drug use. The Senior R programmer/analyst will support this mission, working with a tight-knit, helpful, dedicated group of friendly people including approximately 30 Harvard Medical School faculty and 80 support members. The Senior R Programmer/Analyst will join a group of 9 experienced analysts. Division research is particularly focused on the use of large, administrative healthcare databases, such as health insurance claims and electronic health records, but may also be based on surveys and randomized trials.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

1. Support faculty and other research staff with the creation of analytic data files and the conduct of statistical analyses.
2. Responsible for loading, validating, documenting, managing, and analyzing data for both internal and collaborative research projects.
3. Responsible for assisting with data storage and management issues around both new and ongoing projects within the Division.
4. Responsible for working with other research staff within the Division to help specify appropriate analytical data files for the research question under investigation.
5. Responsible for creating and carefully documenting all derived analytical data files so that they can be understood and used by other members of the research team.
6. Participate in monthly programmer team meetings.
7. Mentor junior programmers/analysts.

QUALIFICATIONS:
- 3 years of experience required, more than 5 years of experience with programming in a health care environment preferred
- Proficiency with R.
- Experience with health care claims data desirable.
- Minimum Bachelor's degree, Master's degree preferred.

SKILLS/ABILITIES/COMPETENCIES REQUIRED:
- attention to detail
- ability to manage and prioritize multiple projects
- experience working in a UNIX environment
- ability to work effectively as a member of a multidisciplinary research team
- ability to collaborate effectively with other programmers/analysts working with other programming languages (e.g. SAS)

ADDITIONAL DESIRED SKILLS (these skills are considered a plus but are not required):
- basic knowledge of SAS/BASE, SAS/SQL, SAS/STAT procedures
- experience with relational databases
- graduate education in epidemiology, biostatistics, or computer science

HOSPITAL WIDE RESPONSIBILITIES:
Works within legal, regulatory, accreditation and ethical practice standards relevant to the position and as established by BWH/Partners; follows safe practices required for the position; complies with appropriate BWH and Partners policies and procedures; fulfills any training required by BWH and/or Partners, as appropriate; brings potential matters of non-compliance to the attention of the supervisor or other appropriate hospital staff.

EEO Statement:
BWH is an Affirmative Action Employer.   By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Primary Location: MA-Boston-BWH Boston Main Campus
Work Locations: BWH Boston Main Campus 75 Francis St, Boston, MA 02115
Job: Business and systems Analyst
Organization: Brigham & Women's Hospital (BWH)
Schedule: Full-time
Standard Hours: 40
Shift: Day Job
Posted Shift Description: Day 40 hrs -- hybrid
Employee Status: Regular
Recruiting Department: BWH Department Of Medicine / Pharmocoepidemiology

Apply Here

Research Assistant I

Research Assistant I / Day/ 40 Hrs Pharmacoepidemiology & Pharmacoeconomics, DOM - (3230993)  

GENERAL SUMMARY/ OVERVIEW STATEMENT:

Working under the direction of the Research Manager, Division Chief, and faculty of the Division of Pharmacoepidemiology and Pharmacoeconomics, the Research Assistant is responsible for the daily organization, coordination, and conduct of activities related to studies of the safe and effective use of medications in a variety of contexts. The majority of research in the Division is neither clinical nor bench science, and is conducted in an office setting with relatively minimal patient interaction. Please see Division website for more information on faculty and research topics.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

The typical Research Assistant’s duties are a combination of research and operational tasks. Research tasks include, but are not limited to, data management and manipulation (MS Excel, statistical software), data entry relevant to studies, conducting inquiries on various policy initiatives, performing literature searches, generating graphs and figures, drafting review board proposals, conducting interviews, gathering research materials for ongoing and future research projects as needed, and other duties as needed.

Operational tasks ensure that the work in the entire Division as well as individual projects run efficiently.   These include a variety of project and office management elements (scheduling, website, and mailing list support). Prospective start date is in Spring 2023 and rquires a minimum one-year commitment.

QUALIFICATIONS:

BA/BS required. Strong attention to detail and ability to manage multiple priorities is a must. Competency with MS Excel, MS Word, MS PowerPoint is required; familiarity with R, SAS, or Python would also be helpful. Prior social science or medical research experience is preferred, and epidemiology and/or biostatistics exposure is a plus. A strong applicant will display the ability to communicate with multiple levels of staff and work effectively with others in a team environment.

SKILLS/ABILITIES/COMPETENCIES:

- BA/BS degree
- Competency with MS Excel, MS Word, MS PowerPoint
- Familiarity with SAS, R, or Python is a plus but NOT a requirement
- Ability to adapt to a fast-paced environment and learn quickly
- Teamwork and cooperation
- Attention to detail and excellent organizational skills
- Ability to manage multiple priorities
- Ability to use independent judgement
- Excellent communication and interpersonal skills, telephone and email etiquette.

WORKING CONDITIONS:

Hybrid with in-person and remote activities in compliance with the facility and MA government guidelines. Professional office environment, business casual. Working as part of a tight-knit group of hardworking friendly people - an internationally acclaimed research unit of 22 Harvard faculty, 65 support staff, and 9 programmers.

HOSPITAL-WIDE RESPONSIBILITIES:

Works within legal, regulatory, accreditation and ethical practice standards relevant to the position and as established by BWH/Partners; follows safe practices required for the position; complies with appropriate BWH and Partners policies and procedures.

EEO Statement:
BWH is an Affirmative Action Employer.   By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Primary Location: MA-Boston-BWH Boston Main Campus
Work Locations: BWH Boston Main Campus 75 Francis St  Boston 02115
Job: Research - Other
Organization: Brigham & Women's Hospital (BWH)
Schedule: Full-time
Standard Hours: 40
Shift: Day Job
Posted Shift Description: Day / 40 hrs
Employee Status: Regular
Recruiting Department: BWH Department of Medicine / Pharmocoepidemiology

Employment at a Partners HealthCare System (“Partners”) affiliate is contingent upon:
- United States Citizenship and Immigration Services rules concerning identity and right to work in the United States
- Multi-state criminal background checks
- Pre-employment health and drug screening and annual compliance with the Influenza Vaccination Policy

Apply Here


Diversity in Pharmacoepidemiology Summer Internship Program

Title: Diversity in Pharmacoepidemiology Summer Internship Program 

General Summary and Overview:
The Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women’s Hospital (BWH) and Harvard Medical School (HMS) invites rising college senior students to participate in an eight-week summer internship program that provides training and skills development in public health research about prescription medications. The long-term goal of the program is to assist students whose backgrounds have historically been underrepresented in biomedical and clinical research to build necessary skills for their career interests in public health, medicine, and other related fields. Students self-identifying as Black/African American, Hispanic/Latinx, American Indian/Alaska Native or Native Hawaiian/Pacific Islander are eligible to apply. US citizens, permanent residents and international students who are matriculated at U.S. colleges/universities may apply (visa restrictions may apply).

Learning Outcomes:

• Experiential and didactic learning through division meetings, including journal club sessions, webinars, and guest presentations
• Completion of a summer capstone project under the supervision of a faculty member with the opportunity to present findings to faculty
• In-depth knowledge of state-level public policies on prescription drug costs, pricing, and access
• Mentoring through career development meetings, one-on-one faculty and intern meetings, and strategic, long-term mentor/mentee pairing to guide further career planning
• Opportunity to audit summer courses offered by faculty at Harvard T.H. Chan School of Public Health and in other Harvard venues

Eligibility:

The fellowship program is best suited for rising senior undergraduate students with an interest in public health, epidemiology, medicine, pharmacy, biostatistics and/or health services research and policy, who are enrolled in a four-year degree program and who self-identify as Black/African American, Native American/Alaskan Native, Hispanic/Latinx or Native Hawaiian/Pacific Islander. Prior research experience is not required, but applicants must be able to convey an interest in research and how this program will help them to achieve their long-term career goals. Quantitative coursework, skills, or experience is preferred, but not required. 

Work environment: Professional Office Environment, Business Casual.  

Application link here.

Application Deadline: February 17, 2023 at 11:59 PM ET

Internship Duration: Monday, June 12th, 2023 -Friday, August 4th, 2023 (8 weeks)

Contact Information: pharmacoepi_intern@bwh.harvard.edu 

EEO Statement:
As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community. We place great value on being a diverse, equitable and inclusive organization as we aim to reflect the diversity of the patients we serve. At Mass General Brigham, we believe in equal access to quality care, employment and advancement opportunities encompassing the full spectrum of human diversity: race, gender, sexual orientation, ability, religion, ethnicity, national origin and all the other forms of human presence and expression that make us better able to provide innovative and cutting-edge healthcare and research.

Post-doctoral Fellowships in Pharmacoepidemiology:

Sebastian Schneeweiss, MD, MS, ScD
Chief, Division of Pharmacoepidemiology and Pharmacoeconomics
Professor of Medicine, Harvard Medical School
Professor in Epidemiology, Harvard Chan School of Public Health


Department of Medicine
Brigham and Women’s Hospital
1 Brigham Circle, Suite 3030, Boston, MA 02120
P: 617 278-0930 M: 617331-2632
sschneeweiss@bwh.harvard.edu
www.DrugEpi.org

November 28, 2022

The Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women’s Hospital Department of Medicine and Harvard Medical School is accepting applications for post-doctoral fellows in pharmacoepidemiology - applied and methodologically focused. 

The Division includes 25 faculty (Division Team) and 75 staff who work closely together to research how we use medications effectively and improve health. We are a world-leading interdisciplinary research center that brings together the various specialties of medicine, epidemiology, biostatistics, health services research, legal, regulatory and the social sciences to evaluate the effectiveness of prescription drugs in relation to their risks and costs; to study how medications are prescribed and used; to develop methods to optimize prescription drug use; to understand how medicines are approved and regulated after their marketing. The Division is a first-rank training site for graduate students and fellows in a variety of subject areas and methodological research. 

We are seeking self-motivated, diligent, and independent fellows to work with Division faculty in the following areas (please see Division website for more detail): 

  • Answering high-impact questions to inform clinical decision making on the comparative effectiveness and safety of medications in geriatric pharmacoepidemiology by applying and advancing cutting edge methods: Collaborate closely with Division faculty who are leaders in the field of geriatric pharmacoepidemiology. A fellow working in this area will answer critical clinical questions on the prescribing and deprescribing of highly potent (e.g. anticoagulants) and/or potentially inappropriate medications (e.g. antipsychotics or benzodiazepines) and their comparative effectiveness and safety in older adults, leveraging real world data, including administrative claims linked with electronic health records including structure EHR and free-text notes and reports), and a variety of clinical assessment files (e.g., Minimum Data Set [MDS], Outcomes and Assessment Information Set [OASIS], Inpatient Rehabilitation Facility Patient Assessment Instrument [IRF-PAI], with the opportunity to lead several NIH-funded learge research projects. The ideal candidate would be a team player and have a doctoral degree in epidemiology, aging research, or clinical geriatrics. 
  • Answering high-impact questions to inform clinical decision making on the comparative effectiveness and safety of medications in cardio-metabolic and renal conditions by applying and advancing cutting edge methods: A fellow working in this area will collaborate closely with Division faculty who are leaders in the pharmacoepidemiology of cardio-metabolic and renal diseases to answer critical questions on the use of medications and their comparative effectiveness and safety leveraging real-world data, including administrative claims, electronic health records, and clinical registries (PROMISE). Fellows will have the opportunity to lead several important research studies. The ideal candidate would be a team player and have a doctoral degree in pharmacoepidemiology and ideally a clinical background, or a degree in medicine combined with pharmacoepidemiology/epidemiology training.
  • Developing and implementing cutting-edge methods to bridge the gap between randomized clinical trials (RCTs) and real-world evidence (RWE): RCTs and RWE are critical and complementary sources of evidence generation about the benefits and safety of medical products. A fellow working in this area will be involved in several interrelated projects that will leverage individual-level RCT data to explore this complementarity and will be expected to explore and test novel analytical approaches for analysis of RCT and real-world data. A fellow in this area will have the opportunity to leverage the infrastructure from RCT-DUPLICATE's large sample of trial emulations to develop and test methods designed to understand and calibrate results from RCTs and database studies, for example meta-regression techniques to examine teh influence of alternative methods on concordance. Training and experience in statistical modeling and programing is required. Experience with developing prediction models, model validation and calibration approaches, imputation methods, Monte Carlo simulations, and machine learning algorithms is highly desirable. 
  • Conducting impactful pediatric real-world evidence research to advance pediatric care and inform the regulation of medications in children: Up to 50% of medications in the outpatient setting and 80% in the inpatient setting are used off-label in pediatric patients. There is increasing interest in evaluating the suitability of real-world evidence studies to form the basis for supplemental regulatory approval of medications to be used in pediatric patients that were previously approved in adult patients. The fellow will conduct pediatric pharmacoepidemiology studies of medication safety and effectiveness using large claims and electronic health record data sources and studies how it impacts the regulation of medications in children. The ideal candidate will have a doctoral degree and training and experience in pharmacoepidemiology. The fellow will work under the supervision of division faculty with expertise in pharmacoepidemiology and pediatrics, and in collaboration with the Harvard-MIT Center for Regulatory Science. 
  • Evaluating the safety of medication use during pregnancy, primarily using pregnancy cohorts nested in large healthcare utilization databases. A fellow working in this area will collaborate closely with faculty and other members of the Harvard Program on Perinatal and Pediatric Pharmacoepidemiology (www.harvardpreg.org). Fellows will have the opportunity to lead NIH-funded research studies addressing critical questions related to drug safety in pregnancy across multiple clinical areas (e.g., psychiatry, neurology, infectious disease). In addition, fellows will be able to contribute to methods-oriented projects that explore the use of cutting-edge epidemiological and statistical approaches to improve causal inference in this area. Aside from a keen interest in perinatal (pharmaco)epidemiology, the ideal candidate would have a doctoral degree in pharmacoepidemiology/epidemiology and preferably a clinical background, or a degree in medicine combined with pharmacoepidemiology/epidemiology training.

Interested individuals should send their CV and a personal statement to Lewis Seton.