Faculty

Soko Setoguchi, M.D., Dr.P.H., is an Assistant Professor of Medicine at Harvard Medical School and the Director of Safety and Outcome Research in Cardiology and an Associate Physician in the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women's Hospital.  Dr. Setoguchi is an epidemiologist and physician trained in general medicine and cardiology, and is interested in (comparative) effectiveness/safety of cardiovascular medications or cardiovascular safety of commonly prescribed medications. She is also interested in large-database methods for comparative effectiveness/safety research and conducted various comparative effectiveness/safety studies. Dr. Setoguchi is also interested in improving validity of claims data research by linking claims data with other data sources such as registries for cancer, and cardiovascular disease and clinical birth records.

In addition to comparative effectiveness/safety studies, Dr. Setoguchi has been conducting health service and outcome research in patients with cardiovascular diseases such as coronary artery disease and heart failure.  Her recent work demonstrated that the increasing use of recommended cardiovascular medications after myocardial infarctions contributed to improved outcomes in community elderly patients.  Another area of her particular interest is the care and management of heart failure patients, and she has been conducting multiple studies to evaluate management and outcomes in elderly heart failure patients.

Selected Publications

• Setoguchi S, Glynn RJ, Avorn J, Mogun H, Schneeweiss S. Statins and the risk of lung, breast, and colorectal cancer in the elderly. Circulation 2007;115(1):27-33.
• Setoguchi S, Solomon DH, Weinblatt ME, Katz JN, Avorn J, Glynn RJ, Cook EF, Carney G, Schneeweiss S. Tumor necrosis factor alpha antagonist use and cancer in patients with rheumatoid arthritis. Arthritis Rheum 2006;54(9):2757-64. Erratum in: Arthritis Rheum 2006;54(10):3134.
• Charytan DM, Setoguchi S, Solomon DH, Avorn J, Winkelmayer WC. Clinical presentation of myocardial infarction contributes to lower use of coronary angiography in patients with chronic kidney disease. Kidney Int 2007;71(9):938-945.
• Setoguchi S, Stevenson LW, Schneeweiss S. Repeated hospitalizations predict mortality in the community population with heart failure. American Heart Journal 2007;154(2):260-6.
• Setoguchi S, Glynn RJ, Avorn J, Levin R, Winkelmayer WC. Ten-year trends of cardiovascular drug use after myocardial infarction among community dwelling persons ≥65 years of age. American Journal of Cardiology 2007;100(7):1061-1067.
• Kinjo M, Setoguchi S, Solomon DH. Bone mineral density in adults with the metabolic syndrome: analysis in a population-based United States sample. J Clin Endocrinol Metab 2007;92(11):4161-4
• Schneeweiss S, Setoguchi S, Brookhart MA, Canning CF, Wang PS. Comparative safety of conventional and atypical antipsychotic medications: risk of death in British Columbia seniors. CMAJ 2007;176(5):627-32.
• Setoguchi S, Levin R, Winkelmayer WC. Long-term trends of angiotensin converting enzyme inhibitor or angiotensin receptor blocker use after heart failure hospitalization in community-dwelling seniors. International Journal of Cardiology 2008;125(2):172-7.
• Setoguchi S, Glynn RJ, Avorn J, Mittleman MA, Levin R, Winkelmayer WC. Improvements in long-term mortality after myocardial infarction and increased use of cardiovascular drugs after discharge: a 10-year trend analysis. Journal of American College of Cardiology 2008;51(13):1247-54.
• Setoguchi S, Schneeweiss S, Brookhart MA, Glynn RJ, Cook EF. Evaluating uses of data mining techniques in propensity score estimation: a simulation study. Pharmacoepidemiology & Drug Safety 2008;17(6):546-55.