Brigham DMC-sponsored Supplement on Methods for Developing and Analyzing Clinically Rich Data for Patient-Centered Outcomes Research is now published in PDS
An open access supplement to Pharmacoepidemiology and Drug Safety’s released online on May 3, 2012 contains 17 papers presented at the third DEcIDE CER methods symposium, “Research Methods for Comparative Effectiveness (CER) and Patient-Centered Outcomes Research (PCOR)” funded by the Agency for Health Care Research and Quality, through its Effective Health Care program. This supplement is the third published in recent years that have become important resources for investigators to use in designing and conducting comparative effectiveness research studies.
EDITORIAL
- Methods for developing and analyzing clinically rich data for patient-centered outcomes research. S. Schneeweiss, J. D. Seeger, and S. R. Smith
COMMENTARY
ORIGINAL ARTICLES
Enriched Data Sources
- Analyzing partially missing confounder information in comparative effectiveness and safety research of therapeutics. S. Toh, L. A. García Rodríguez, and M. A. Hernán
- Identification of metastatic cancer in claims data. B. L. Nordstrom, J. L. Whyte, M. Stolar, C. Mercaldi, and J. D. Kallich
- Linkage of routinely collected oncology clinical data with health insurance claims data —an example with aromatase inhibitors, tamoxifen, and all-cause mortality. D.D. Dore, C. Liang, N. Ziyadeh, H. Norman, M. Bayliss, and J.D. Seeger
- Merging of NCI-funded cooperative oncology group data with an administrative data source to develop a more effective platform for clinical trial analysis and comparative effectiveness research: A report from the Children’s Oncology Group. R. Aplenc, B. T. Fisher, Y. S. Huang, Y. Li, T. A. Alonzo, R. B. Gerbing, M. Hall, D. Bertoch, R. Keren, A. E. Seif, L. Sung L, P. C. Adamson, A. Gamis
- Incorporating initial treatments improves performance of a mortality prediction model for patients with sepsis. T. Lagu, M. B. Rothberg, B. H. Nathanson, J. S. Steingrub, and P. K. Lindenauer
- Evaluation of total hip arthroplasty devices using a total joint replacement registry. E. W. Paxton, C. F. Ake, M. C. S. Inacio, M. Khatod, D. Marinac-Dabic, and A. Sedrakyan
Improved Confounding Adjustment
- Prior Event Rate Ratio (PERR) adjustment: Numerical studies of a statistical methods to address unrecognized confounding in observational studies. M. Yu, D. Xie, X. Wang, M. G. Weiner, and R. L. Tannen
- One-to-many propensity score matching in cohort studies. J. A. Rassen, a. a. shelat, J. Myers, R.J. Glynn, K. J. Rothman, and S. Schneeweiss
- Performance of propensity score-based methods when exposed and comparison groups originate from different data sources. B. G. Hammill, L. H. Curtis, and S. Setoguchi
- Confronting ‘confounding by health system use’ in Medicare Part D: Comparative effectiveness of propensity score approaches to confounding adjustment. J. M. Polinski, S. Schneeweiss, R. J. Glynn, J. Lii, and J. A. Rassen
- Dynamic marginal structural modeling to evaluate the comparative effectiveness of more or less aggressive treatment intensification strategies in adults with type 2 diabetes. R. Neugebauer, B. Fireman, J. A. Roy, P. J. O’Connor, and J. V. Selby
- Simulation study of instrumental variable approaches with an application to a study of the antidiabetic effect of bezafibrate. B. Cai, S. Hennessy, J. H. Flory, D. Sha, T. R. Ten Have, and D. S. Small
Heterogeneity of Treatment Effect
- Assessing the applicability of trial evidence to a target sample in the presence of heterogeneity of treatment effect. C. O. Weiss, J. B. Segal, and R. Varadhan
Methods for Emerging Therapies
- Comparative effectiveness research using matching-adjusted indirect comparison: An application to treatment with guanfacine extended release or atomoxetine in children with ADHD and co-morbid oppositional defiant disorder. J. Signorovitch, M.H. Erder, J. Xie, V. Sikirica, M. Lu, P.S. Hodgkins, and E.Q. Wu
- Role of disease risk scores for comparative effectiveness with emerging therapies. R. J. Glynn, J. J. Gagne, and S. Schneeweiss
Randomized Designs That Mimic Routine Care
- Reweighted mahalanobis distance matching for cluster-randomized trials with missing Data. R. A. Greevy, C. G. Grijalva, C. L. Roumie, C. Beck, A. M. Hung, H. J. Murff, X. Liu, and M. R. Griffin