The Agency for Healthcare Research and Quality, through its Effective Health Care Program, is sponsoring a fourth invitational symposium on research methods for comparative effectiveness research (CER) and patient-centered outcomes research (PCOR). This 2-day symposium and workshop will be held on June 12 and 13, 2012 at the AHRQ Conference Center in Rockville, Maryland. The symposium is a follow-up to the AHRQ conferences on Methods in Comparative Effectiveness and Safety Research hosted in 2006, 2009, and 2011; papers presented at the first two conferences were published in a Medical Care Supplement (copies may be downloaded from or and the proceedings of the 2011 symposium are forthcoming soon in a Pharmacoepidemiology and Drug Safety journal supplement. These AHRQ methods symposia and the associated journal supplements have become important resources for investigators to use in designing and conducting comparative effectiveness studies.

The theme of the 2012 symposium is “From Efficacy to Effectiveness”. Invited experts will give podium presentations on innovative research methods to evaluate mechanisms that contribute to the differences in the results of randomized clinical trials (i.e., efficacy studies) and observational studies conducted in real world settings (i.e., outcomes and effectiveness research). The proceedings of the symposium will be published as a special journal supplement in 2013 (Journal TBD). The symposium aims to provide a forum for scholarly deliberation of new and emerging research methods by scientists working in different disciplines and across settings. In addition to podium presentations, there will be a poster session featuring abstracts selected through a blinded peer-review process. A preliminary program may be found at: 2012 Symposium Agenda.

Live Web Broadcast

To expand access to the symposium proceedings, AHRQ will provide a live broadcast of the authors’ slides and audio presentations via the internet. If you are interested in viewing a broadcast of the workshop or the symposium, we invite you to register through the website listed below. Although there is no charge for registration, seats are limited and we ask that you register only when you are sure you can attend the full workshop on June 12 and/or the all symposium session on either June 12 or June 13. Insofar as possible, we ask that individuals from the same organization gather together at one location for the broadcast to conserve seating. This will allow as many people as possible to view the presentations. Registration is on a first-come, first-served basis, so it is recommended that you commit early to ensure a reserved seat.

Registration: Live Web Broadcast

Should you have any questions regarding the event, please feel free to contact Scott Smith (, Sebastian Schneeweiss (, or Elizabeth Robinson (

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