Kelly O’Keefe, MPH
Brigham & Women’s Hospital
Department of Medicine
Division of Pharmacoepidemiology & Pharmacoeconomics
1620 Tremont Street, Suite 3030,
Boston, MA 02120
Phone: 617-278-0930 | Fax: 617-232-8602
Kelly O’Keefe, MPH, is the Research Manager for the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women’s Hospital. After graduating magna cum laude with her BA in Psychology at Boston University, Kelly spent her post-college years doing fMRI research in Alzheimer’s disease here at BWH. She returned to BU for her MPH, where she concentrated in Health Policy and Management within the Pharmaceutical Assessment Management and Policy tract, and joined DoPE in 2010 upon graduation. She currently manages and coordinates the research efforts for the division, and heads up the RA team at our Louis Pasteur location.
Selected Publications | Current PubMed Search Results
- O’Keefe, K. “Cognitive decline associated with loss of hippocampal activation on longitudinal fMRI in non-demented older subjects.” Talk given at Organization for Human Brain Mapping, Melbourne, Australia, 2008.
- O’Keefe K, Vannini P, O’Brien J, LaViolette P, Putcha D, Becker JA, et al (2009): Precuneus Amyloid Deposition Associated With Altered Hippocampal Activation During Encoding and Memory Performance in Asymptomatic Older Controls. Human Amyloid Imaging, Seattle, Washington.
- O’Brien J, O’Keefe K, LaViolette P, DeLuca A, Blacker D, Dickerson B, and Sperling R (2010): Longitudinal fMRI in non-demented elderly reveals loss of hippocampal function with clinical decline. Neurology 74;1969-1976.
- Putcha D, O’Keefe K, Laviolette P, O’Brien J, Greve D, Rentz DM, et al (2011): Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults. Hum Brain Mapp 32(12):2027-44.
- Pihlajamaki M, O’Keefe K, Bertram L, Tanzi RE, Dickerson B, Blacker D, and Sperling R (2010): Evidence of altered posteromedial cortical fMRI activity in subjects at risk for Alzheimer disease. Alzheimer Dis. Assoc. Disord. 24(1):28-36.
- Pihlajamaki M, O’Keefe K, O’Brien J, Blacker D, and Sperling R (2011): Failure of repetition suppression and memory encoding in aging and Alzheimer disease. Brain Imaging Behav 5: 36-44.
- Sperling R, LaViolette P, O’Keefe K, O’Brien J, Rentz D, Pihlajamaki M, et al (2009): Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron 63:178-188.
- Vannini P, O’Brien J, O’Keefe K, Pihllajamaki M, DeLuca A, LaViolette P, and Sperling R (2011): What goes down must come up: Role of the posteromedial cortices in encoding and retrieval. Cerebral Cortex 21: 2-34.
- Putcha D, Brickhouse M, O’Keefe K, Sullivan C, Rentz D, Marshall G, Dickerson B, and Sperling R (2011): Hippocampal hyperactivation associated with cortical thinning in Alzheimer’s disease signature regions in non-demented elderly adults. J Neurosci 31(48):17680-8.
- Wang L, LaViolette P, O’Keefe K, Putcha D, Bakkour A, Van Dijk K, et al (2010): Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals. Neuroimage 51: 910-917.
- Atri A, O’Brien JL, Sreenivasan A, Rastegar S, Salisbury S, DeLuca AN, O’Keefe KM, LaViolette PS, Rentz DM, Locascio JJ, and Sperling RA (2011): Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials. Arch Neurol 68(5):599-606.
- Gagne JJ, Thompson L, O’Keefe K, Kesselheim AS (2014): Innovative research methods for studying treatments for rare diseases: methodological review. British Medical Journal 349: g6802.
- Kesselheim AS, McGraw S, Thompson L, O’Keefe K, Gagne JJ. Development and use of new therapeutics for rare diseases: views from patients, caregivers, and advocates. The Patient: Patient-Centered Outcomes Research 2015 [in press].