Brigham & Women’s Hospital
Department of Medicine
Division of Pharmacoepidemiology & Pharmacoeconomics
1620 Tremont Street, Suite 3030,
Boston, MA 02120
Phone: 617-278-0930 | Fax: 617-232-8602
William Shrank, MD, MSHS, is serving as part-time faculty in the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women’s Hospital.
Dr. Shrank lives in Washington D.C. where he is the Director of Rapid-Cycle Evaluation at the Center for Medicare and Medicaid Innovation at CMS. He leads the evaluation of all payment and health-system delivery reform programs supported by the Innovation Center as well as all Congressionally mandated demonstration programs. He developed the rapid-cycle strategy to promote continuous quality improvement and rapid spread of effective programs while maintaining scientific rigor. He also oversees the intramural research enterprise for CMS.
At BWH, Dr. Shrank’s research is focused on evaluating quality in pharmacologic care, enhancing adherence to chronic medications, and improving prescription drug labels. He was the founder and principal investigator of the CVS Caremark Harvard Partnership for Improving Medication Adherence, a multi-disciplinary research initiative to improve how patients take medication, as well as the Pharmacy Care Research Institute, also funded by CVS Caremark. He received a career development award from the National Heart, Lung, Blood Institute of the National Institutes of Health to evaluate interventions to improve rational prescribing in cardiovascular disease, and a Pioneer Award from the Robert Wood Johnson Foundation to study the effect of labeling on medication use. He has published over 100 articles in the peer-reviewed literature focusing on prescription drug use.
Dr. Shrank serves or has served on national advisory committees for the FDA, CMS, DHHS, AHRQ, the Society of General Internal Medicine, the American College of Physicians Foundation, and the U.S. Pharmacopeia. He attended Brown University, received his M.D. from Cornell University, and did his residency training in Internal Medicine at Georgetown University. He served on the clinical faculty in General Internal Medicine at University of Colorado Health Sciences Center before finishing a health services research fellowship at UCLA, Rand, and the West Los Angeles VA Hospital where he earned an M.S. in Health Services from UCLA. Until 2011, he practiced general internal medicine at the Brigham and Women’s Hospital.
Selected Publications | Current PubMed Search Results
- Shrank WH, Hoang T, Ettner SL, Glassman P, Delapp D, London R, Avorn J, Asch SM. The Implications of Choice: Prescribing Generic or Preferred Formulary Medications Improves Adherence to Chronic Medications. Archives of Internal Medicine 2006 Feb;166:332-7.
- Shrank WH, Agnew-Blais J, Choudhry NK, Wolf MS, Kesselheim A, Avorn J, Shekelle P. The variability and quality of medication container labels. Archives of Internal Medicine 2007 Sep 10;167(16):1760-5.
- Kesselheim AS, Misono AS, Lee JL, Stedman MR, Brookhart MA, Choudhry NK, Shrank WH. The Clinical Equivalence of Generic and Brand-Name Drugs Used in Cardiovascular Disease: A Systematic Review and Meta-Analysis. Journal of the American Medical Association 2008 Dec 3;300(21):2514-26.
- Shrank WH, Cox E, Fischer MA, Mehta J, Choudhry NK. Patient perceptions of generic medications. Health Affairs. 2009;28(2): 546–556.
- Shrank WH, Choudhry NK, Agnew-Blais J, Federman AD, Lieberman JN, Liu J, Kesselheim AS, Brookhart MA, Fischer MA. State generic substitution laws can lower drug outlays under medicaid. Health Affairs. 2010;29(7):1383-90.
- Greene JA, Choudhry NK, Kilabuk E, Shrank WH. Online social networking by patients with diabetes: A qualitative evaluation of communication with Facebook. Journal of General Internal Medicine. 2011;26(3):287-92.
- Shrank WH, Choudhry NK, Fischer MA, Avorn J, Powell M, Schneeweiss S, Lieberman JN, Dollear T, Brennan TA, Brookhart MA. The epidemiology of prescriptions abandoned at the pharmacy. Annals of Internal Medicine. 2010;153(10):633-40.
- Choudhry NK, Avorn J, Glynn RJ, Antman EM, Schneeweiss S, Toscano M, Reisman L, Fernandes J, Spettell C, Lee JL, Levin R, Brennan T, Shrank WH; Full coverage for preventive medications after myocardial infarction. New England Journal of Medicine. 2011;365(22):2088-97.
- Shrank WH, Chouhdry NK. Time to fill the donuts–Health Reform and Medicare Part D. New England Journal of Medicine. 2011;364(7):598-601.
- Shrank WH. The Other Side of Medication Non-Adherence: Our Bulging Medicine Cabinets. New England Journal of Medicine. 2011;364(17):1591-3.