Major accomplishments of Division faculty

  • Development of new methodologies for computer-intensive analysis of very large datasets of prescriptions and clinical encounters to identify drug risks;
  • Quantification of the risk of adverse events following use of specific drugs or drug classes (e.g., statins, biologics, anti-Parkinsonian agents);
  • Evaluation of government policies affecting medication use to define their clinical and economic consequences;
  • Definition of important confounders that can distort the results of observational studies of drug effects;
  • Elucidation of the prevalence and predictors of poor adherence to prescribed regimens (non-compliance);
  • Creation, implementation, and evaluation of educational outreach programs (“academic detailing”) to improve prescribing in primary care, teaching hospitals, and nursing homes;
  • Assessment of the cost-effectiveness of particular medications and drug-use strategies;
  • Implementation of a randomized controlled trial of changes in drug coverage policies in thousands of patients, to measure effects on compliance and clinical outcomes;
  • Analyses of the effects of intellectual property law on the development, utilization, and costs of medications.