Brigham and Women’s Hospital
Department of Medicine
Division of Pharmacoepidemiology & Pharmacoeconomics
1620 Tremont Street, Suite 3030,
Boston, MA 02120
Phone: 617-278-0925 | Fax: 617-232-8602
Martin Kulldorff, PhD, is a biostatistician in the Division of Pharmacoepidemiology and Pharmacoeconomics at the Brigham and Women’s Hospital. His current research centers on developing new statistical methods for post-market drug and vaccine safety surveillance.
He has developed new sequential statistical methods for near real-time post-market drug and vaccine safety surveillance, where the purpose is to use weekly, monthly or other frequent data feeds to find potential safety problems as soon as possible. He has developed a tree-based scan statistic for post-market drug and vaccine safety surveillance. Keeping the outcome definitions flexible, the method simultaneously evaluates thousands of potential adverse events and groups of related events, adjusting for the multiple testing inherent in such an approach. Another more recent area of methodological work is the development of new statistical methods for evaluating the comparative safety of different childhood vaccine schedules. A fourth major area of methodological research is spatial and spatio-temporal disease surveillance, for which Dr. Kulldorff has developed various scan statistics for disease cluster detection and investigation; and for the early detection of infectious disease outbreaks.
As a biostatistician, Dr. Kulldorff also do collaborative and consulting work with epidemiologists and clinicians, using a wide variety of study designs and methods for many different types of diseases.
Dr. Kulldorff received his bachelor’s degree in mathematical statistics from Umeå University in Sweden, and his doctorate in operations research from Cornell University.
Selected Publications | Current PubMed Search Results
- Lieu TA, Ray GT, Klein NP, Chung C, Kulldorff M. Geographic clusters in under immunization and vaccine refusal. Pediatrics, 2015, 135:280-289.
- Silva I, Kulldorff M. Continuous versus group sequential analysis for vaccine and drug safety surveillance. Biometrics, 2015, in press.
- Maro J, Brown J, del Pan G, Kulldorff M. Minimizing signal detection time in postmarket sequential analysis: balancing positive predictive value and sensitivity. Pharmacoepidemiology and Drug Safety, 2014, 23:839-48.
- Yih WK, Lieu TA, Kulldorff M, Martin D, McMahill-Walraven CN, Platt R, Selvam N, Selvan M, Lee GM, Nguyen M. Intussusception Risk after Rotavirus Vaccination in U.S. Infants. New England Journal of Medicine, 2014, 370:503-12.
- Maro J, Brown J, Kulldorff M. Medical Product Safety Surveillance: How Many Databases to Use? Epidemiology, 2013, 24:692-699.
- Kulldorff M, Dashevsky I, Avery TR, Chan KA, Davis RL, Graham D, Platt R, Andrade SE, Boudreau D, Gunter MJ, Herrinton LJ, Pawloski P, Raebel MA, Roblin D, Brown JS. Drug safety data mining with a tree-based scan statistic. Pharmacoepidemiology and Drug Safety, 2013, 22:517-523.
- Kulldorff M, Davis RL, Kolczak M, Lewis E, Lieu T, Platt R. A maximized sequential probability ratio test for drug and vaccine safety surveillance. Sequential Analysis, 2011, 30:58-78.
- Greene SK, Kulldorff M, Yin R, Yih WK, Lieu TA, Weintraub ES, Lee GM. Near real-time vaccine safety surveillance with partially accrued data. Pharmacoepidemiology and Drug Safety, 2011, 20:583-590.
- Yih WK, Kulldorff M, Fireman BH, Shui IM, Lewis EM, Klein NP, Baggs J, Weintraub ES, Belongia EA, Naleway A, Gee J, Platt R, Lieu TA. Active Surveillance for Adverse Events: The Experience of the Vaccine Safety Datalink Project. Pediatrics, 2011, 127:S54-64.
- Klein NP, Fireman B, Yih WK, Lewis E, Kulldorff M, Ray P, Baxter R, Hambidge S, Nordin J, Naleway A, Belongia EA, Lieu T, Baggs J, Weintraub E, for the Vaccine Safety Datalink. Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. Pediatrics, 2010, 126, e1-8.
- Li L, Kulldorff M. A conditional maximized sequential probability ratio test for pharmacovigilance. Statistics in Medicine, 2010, 29:284-295.
- Lieu TA, Kulldorff M, Davis RL, Lewis EM, Weintraub E, Yih WK, Yin R, Brown JS, Platt R. Real-time vaccine safety surveillance for the early detection of adverse events. Medical Care, 2007, 45:S89-95.
- Kulldorff M. Tests for spatial randomness adjusting for an inhomogeneity: A general framework. Journal of the American Statistical Association, 2006, 101:1289-1305.
- Kulldorff M, Heffernan R, Hartman J, Assunção R, Mostashari F. A space-time per-mutation scan statistic for disease outbreak detection. PLoS Medicine, 2005, 2:216-224.
- Kulldorff M, Fang Z, Walsh S. A tree-based scan statistic for database disease surveillance. Biometrics, 2003, 59:323-331.
- Kulldorff M. Prospective time-periodic geographical disease surveillance using a scan statistic. Journal of the Royal Statistical Society, 2001; A164:61-72
- Kulldorff M. A spatial scan statistic. Communications in Statistics: Theory and Methods, 1997; 26:1481-1496.
TreeScanTM: Software for the tree-based and tree-temporal scan statistic.
SaTScanTM: Software for the spatial, temporal and space-time scan statistics.
R Sequential Package: Exact Sequential Analysis for Poisson and Binomial Data.